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October 12, 2025The Journal of Clinical Endocrinology & MetabolismOpen Access

Rates and Pattern of Antifracture Drug Use in 6475 Adults and Children With Osteogenesis Imperfecta

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Authors

WLWinnie LiuJZJingyi ZhangSDShanette G. Daigle

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Overview

Cohort study reveals antifracture drug use of 25.9% in osteogenesis imperfecta patients, highlighting underutilization.

Key Points

  • Antifracture drug use was found to be 25.9% among individuals with osteogenesis imperfecta.
  • The use of antifracture drugs varied significantly with age, being highest in children and lower in young adults.
  • Most prescribed antifracture drugs were bisphosphonates, utilized across all age groups and OI severity levels.
  • Overall rates of antifracture drug use are lower than previously reported, indicating potential underutilization in the general population.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68ebffcfdef9fcb308ff2339https://doi.org/10.1210/clinem/dgaf514
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mortality and fracture risk in children with osteogenesis imperfecta: Results from the French nationwide hospital discharge database2025
  2. 2Atypical Femoral Fractures in Adult Patients with Classical Osteogenesis Imperfecta2026
  3. 3Bone fragility persists in long-term bisphosphonate-treated oim mice despite sex-specific changes in bone quality.2026
  4. 4Epidemiological profile of patients with osteogenesis imperfecta assisted at a reference children's hospital in Brazil2024
  5. 5The natural history of osteogenesis imperfecta: a systematic review2026