Risks of Serious Adverse Events Associated With Non‐Steroidal Anti‐Inflammatory Drugs in Orthopaedic Surgery. A Systematic Review With Meta‐Analysis and Trial Sequential Analysis

This systematic review with meta-analysis was aimed at assessing non-steroidal anti-inflammatory drug treatments for reported serious adverse effects in post-operative analgesia trials in orthopedic surgical cohorts. These drugs are routinely part of modern multimodal or pre-emptive analgesia treatment routines. The published evidence was generelly assessed to have a high risk of bias or low certainty for this specific question. No clear difference in reported event risk between this type of drug and placebo was found, though it is not clear that this is conclusive.