Key result
Data on adverse events of perioperative non-opioid analgesics are sparse and inconclusive, with paracetamol showing trivial AEs and NSAIDs having inconclusive cardiovascular and mortality risks.
Why the study?
What are the adverse events associated with common perioperative non-opioid analgesics?
Population
Patients experiencing post-operative pain
Design
Review
Authors
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Inconclusive perioperative NSAID AE data warrant clinical caution; leaves open need for large trials with prolonged follow-up.
What are the adverse events associated with common perioperative non-opioid analgesics?
Reporting of adverse events for common perioperative non-opioid analgesics is sparse and mostly confined to the immediate post-operative period, highlighting a need for large trials with prolonged observation.
Mathiesen et al. (2014) conducted a review in Post-operative pain. Perioperative non-opioid analgesics (paracetamol, NSAIDs, glucocorticoids, gabapentinoids) was evaluated on Adverse events. Data on adverse events of perioperative non-opioid analgesics are sparse and inconclusive, with paracetamol showing trivial AEs and NSAIDs having inconclusive cardiovascular and mortality risks.