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April 15, 2026Oral DiseasesOpen Access

Efficacy of a Hyaluronic Acid‐Based Gel Versus 0.20% Chlorhexidine in Nonsurgical Periodontal Therapy: A Single‐Blind Randomized Clinical Trial

Andrea Scribante Maurizio Pascadopoli Matteo Pellegrini Karyna Chekal Andrea Butera

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Key Points

The aim is to determine the efficacy of a hyaluronic acid-based gel compared to 0.20% chlorhexidine in nonsurgical periodontal therapy.
Single-blind randomized clinical trial design
Comparison between hyaluronic acid gel and chlorhexidine
Assessment of periodontal parameters like PPD and CAL
Hyaluronic acid gel significantly improved probing pocket depth (PPD)
Enhanced clinical attachment level (CAL) observed with HA gel
Demonstrated safety and clinical benefits over chlorhexidine

Implication

Randomized clinical trial compares hyaluronic acid gel and chlorhexidine, showing improved outcomes in periodontal treatment.

Discussion

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Cite This Study

Scribante et al. (2026) studied this question.

synapsesocial.com/papers/69e3216540886becb654098f https://doi.org/10.1111/odi.70345

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