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May 7, 2026AntibioticsOpen Access

The Efficacy of Sodium Hypochlorite in Combination with Hyaluronic Acid as an Adjunct to Non-Surgical Periodontal Treatment: A Systematic Review

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Authors

QFQonita FeriaISInggrid Ratna Sari SoegihartoNPNanda Denia Astika Putri

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Overview

Systematic review evaluates sodium hypochlorite and hyaluronic acid's role in improving periodontal outcomes, suggesting benefits in deep pockets.

Key Points

  • To evaluate the effectiveness of sodium hypochlorite combined with hyaluronic acid in non-surgical periodontal treatment.
  • Systematic review of scientific literature
  • Searched five electronic databases
  • Used PRISMA criteria for study selection
  • Examined randomized studies using Cochrane Risk of Bias tool
  • Reviewed case series studies with Joanna Briggs Institute checklist.
  • Included four studies: two randomized controlled trials and two case series
  • PPD reduction ranged from 1.5 to 5.8 mm
  • CAL gain ranged from 1.5 to 5.3 mm
  • BOP reduction ranged from 57.5% to 65.6%
  • Improvements more pronounced in deeper periodontal pockets.

Cite This Study

Feria et al. (2026) studied this question.

synapsesocial.com/papers/69fbe357164b5133a91a285dhttps://doi.org/10.3390/antibiotics15050428
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hyaluronic Acid and Sodium Hypochlorite as Adjunctive Therapeutic Options for Patients with Periodontal Disease: A Systematic Review2026
  2. 2Microbiological Effects of Sodium Hypochlorite/-Amino Acids and Cross-linked Hyaluronic Acid Adjunctive to Non-surgical Periodontal Treatment.2024 · 7 citations
  3. 3Effects of hyaluronic acid as an adjunct to nonsurgical treatment of periodontal pockets: a narrative review.2025
  4. 4Effect of sodium hypochlorite and hyaluronic acid in subgingival re-instrumentation - a randomized clinical trial.2026
  5. 5Effect of sodium hypochlorite and hyaluronic acid in subgingival re-instrumentation – a randomized clinical trial2026 · 2 citations