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May 31, 2026BMC Oral HealthOpen Access

Effect of sodium hypochlorite and hyaluronic acid in subgingival re-instrumentation – a randomized clinical trial

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Authors

GJGert JungbauerUniversity of BernFSFabienne StalderUniversity of BernSMSteffen MüllerUniversity of Regensburg

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Implication

Randomized trial shows added sodium hypochlorite and hyaluronic acid improves outcomes in subgingival re-instrumentation, suggesting better treatment effectiveness.

Key Points

  • This study aims to evaluate the additional effects of sodium hypochlorite and hyaluronic acid during subgingival re-instrumentation.
  • Randomized trial comparing standard subgingival re-instrumentation to adjunctive sodium hypochlorite and hyaluronic acid.
  • Included 42 patients with clinical parameters and microbiological analysis conducted at baseline, 3, and 6 months.
  • Utilized ELISA for immunological biomarkers and qPCR to assess periopathobionts.
  • In the test group, probing depth reduced by 0.50 mm (1.38 mm vs. 0.88 mm; p = 0.008) compared to control.
  • Clinical attachment level gained 0.57 mm (1.07 mm vs. 0.50 mm; p = 0.017) in the test group.
  • 88.1% reduction in residual pockets in the test group vs. 38.1% in the control group.

Cite This Study

Jungbauer et al. (2026) studied this question.

synapsesocial.com/papers/6a1bd1555783ba022b6fcef7https://doi.org/10.1186/s12903-026-08694-9
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