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This paper aims to assess the role of metabolomics in understanding thyroid dysfunction and its metabolic effects.

April 18, 2026MetabolitesOpen Access

The Thyroid–Metabolism Axis: Pathways of Dysregulation and the Effects of Treatment

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This review explores metabolomics to improve outcomes in thyroid dysfunction, indicating a shift in diagnostic practices.

This paper aims to assess the role of metabolomics in understanding thyroid dysfunction and its metabolic effects.
Reviewed metabolomic signatures associated with thyroid dysfunction
Evaluated limitations and variability across existing studies
Summarized five metabolic hubs influenced by thyroid hormones
Discussed clinical implications of integrative approaches like genomics
Identified metabolic profiles that characterize thyroid dysfunction
Demonstrated limitations of using TSH alone for diagnosis
Highlighted the potential of metabolomics in risk stratification
Outlined challenges for clinical adoption of metabolomics, including standardization issues

Curcio et al. (2026) studied this question.

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