Linkage Between miR‐218‐2 (rs11134527) Genetic Polymorphism and Breast Cancer Risk: A Case‐Control Study in the Bangladeshi Women

Background and Aims The growth and spread of breast carcinoma are influenced by genetic factors. Diverse forms of cancer have been reported to display multiple subtypes of the microRNA gene. Therefore, the current study aimed to explore the connection between the miR‐218‐2 (rs11134527) and breast cancer risk. Methods A total of 303 participants (158 breast cancer patients and 145 healthy controls) were enrolled. Clinical and demographic data were collected through structured questionnaires and hospital records. Genotyping of miR‐218‐2 rs11134527 was performed using the T‐ARMS‐PCR technique. Statistical analyses were conducted with SPSS v25.0 and MedCalc v19.0.7. The adjusted odds ratio (aOR) using binary logistic regression that controls for age and BMI was employed to investigate the relationship between the targeted SNPs and the risk of breast cancer. Results Among the patients, invasive ductal carcinoma was the most frequent histological type (49.61%), followed by lobular carcinoma (17.22%). Grade II tumors (63.75%) were predominant. Ultrasound (64.18%) and biopsy (68.66%) were the most common diagnostic tools. Chemotherapy was the principal treatment (62.12%), with cyclophosphamide (69.62%), doxorubicin (53.80%), and paclitaxel (56.33%) as the most prescribed agents. Genotype analysis revealed that individuals carrying the AA genotype had a significantly higher risk of breast cancer than those with GG (additive model 2: OR = 2.48, 95% CI = 1.12–5.48, p = 0.025). Significant associations were also observed under the recessive model (AA vs. GG + AG: OR = 1.96, 95% CI = 1.0–3.86, p = 0.051) and the allelic model (A vs G: OR = 1.59, 95% CI = 1.06–2.39, p = 0.026). Conclusion The miR‐218‐2 rs11134527 A allele confers an increased risk of breast cancer in Bangladeshi women, supporting its potential role as a population‐specific genetic biomarker for susceptibility assessment.