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April 19, 2026Exercise and Sport Sciences Reviews0 citations

Reactive Hyperemia: revisiting a key vascular feature of cardiorespiratory fitness.

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NBNicholas BlackmondJMJuan M. MuriasRSROGERIO NOGUEIRA SOARES

Key Result

Reactive hyperemia captures training-related vascular adaptations more effectively than conduit artery dilation in healthy endurance-trained individuals.

Key Points

  • This research aims to assess the efficacy of reactive hyperemia in reflecting vascular adaptations related to cardiorespiratory fitness compared to flow-mediated dilation.
  • Evaluated reactive hyperemia responses in endurance-trained individuals
  • Compared findings with traditional flow-mediated dilation measures
  • Analyzed both macrovascular and microvascular aspects of vascular function
  • Reactive hyperemia demonstrated stronger links to training-related vascular changes
  • It provided a better reflection of peripheral remodeling compared to flow-mediated dilation
  • The approach highlighted specific microvascular responses associated with increased cardiorespiratory fitness

Structured PICO

Does reactive hyperemia capture training-related vascular adaptations more effectively than flow-mediated dilation in healthy endurance-trained individuals?

P
Population
Healthy endurance-trained individuals
I
Intervention
Reactive hyperemia (RH) evaluation
C
Comparator
Flow-mediated dilation (FMD)
O
Outcome
Detection of endurance exercise training-mediated vascular adaptationssurrogate

Reactive hyperemia may be a superior physiological marker compared to flow-mediated dilation for assessing vascular adaptations to endurance training in healthy individuals.

Abstract

Although flow-mediated dilation (FMD) is a well-established marker of conduit artery endothelial function, it is not optimally suited to detect endurance exercise training-mediated vascular adaptations in healthy individuals. Herein, we evaluate reactive hyperemia (RH), adding resistance-vessel and microvascular responses, as a physiological feature that more closely reflects the peripheral remodeling and physiological environment associated with cardiorespiratory fitness (CRF). SUMMARY: Reactive hyperemia captures training-related vascular adaptations more effectively than conduit artery dilation in healthy endurance-trained individuals.

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Cite This Study

Blackmond et al. (2026) conducted a review in Cardiorespiratory fitness in healthy individuals. Reactive hyperemia (RH) assessment vs. Flow-mediated dilation (FMD) was evaluated on Detection of training-related vascular adaptations. Reactive hyperemia captures training-related vascular adaptations more effectively than conduit artery dilation in healthy endurance-trained individuals.

synapsesocial.com/papers/69e47321010ef96374d8f043https://doi.org/10.1249/jes.0000000000000389
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