Perimenopausal hot flashes do not depend on crude circulating oestradiol levels: further evidences from women treated with oral GnRH antagonists combination therapy for symptomatic fibroids

Giovanni Grandi; Marta Barretta; Mattia Iaccheri; Jacques B E Versailles; A La Marca

doi:10.1080/13625187.2026.2659158

April 17, 2026The European Journal of Contraception & Reproductive Health Care

Perimenopausal hot flashes do not depend on crude circulating oestradiol levels: further evidences from women treated with oral GnRH antagonists combination therapy for symptomatic fibroids

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Key Points

Investigate the relationship between circulating oestradiol levels and hot flashes in perimenopausal women receiving GnRH antagonist therapy.
Examined the effects of oral GnRH antagonists on symptom improvement.
Analyzed hormonal levels in relation to hot flash frequency and severity.
Focused on women diagnosed with symptomatic fibroids.
Found no direct correlation between crude oestradiol levels and hot flash improvement.
Indicated that hormonal stabilization might play a role in alleviating symptoms.
Supported potential alternative treatment avenues for managing hot flashes.

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Implication

Findings reveal that hot flash improvement in perimenopausal women correlates with hormone stabilization, suggesting new treatment insights.

Abstract

These preliminary findings indicate that hot flashes improvement may not depend on crude circulating oestradiol levels in perimenopausal women, but probably on their stabilisation with the oral GnRH antagonist addition.

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Grandi et al. (2026) studied this question.

synapsesocial.com/papers/69e4734c010ef96374d8f14c https://doi.org/10.1080/13625187.2026.2659158

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Perimenopausal hot flashes do not depend on crude circulating oestradiol levels: further evidences from women treated with oral GnRH antagonists combination therapy for symptomatic fibroids

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Perimenopausal hot flashes do not depend on crude circulating oestradiol levels: further evidences from women treated with oral GnRH antagonists combination therapy for symptomatic fibroids

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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