Why the study?
Does hormone therapy affect heart rate variability in recently postmenopausal women with and without vasomotor hot flashes?
Population
150 recently postmenopausal women (72 with and 78 without vasomotor hot flashes)
Comparison
Transdermal estradiol gel, oral estradiol alone… vs Placebo for 6 months
Design
RCT, randomized
Follow-up
6 months
Authors
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Supports preferring transdermal estradiol to preserve HRV in women with hot flashes; extends evidence on route-specific autonomic effects of estrogen.
Does hormone therapy affect heart rate variability in recently postmenopausal women with and without vasomotor hot flashes?
Oral estrogen, particularly when combined with MPA, may adversely affect heart rate variability and increase supraventricular ectopic beats in postmenopausal women compared to transdermal estradiol.
Haapalahti et al. (2011) studied this question.
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