Why the study?
Does hormone replacement therapy (estradiol alone or with norethisterone) improve 24-hour heart rate variability in healthy postmenopausal women?
Population
40 healthy postmenopausal women, 46-63 years of age
Comparison
Continuous 2 mg of estradiol plus 1 mg of… vs Placebo (n=13) for 3 months
Design
RCT, randomly assigned, double-blind, placebo-controlled
Follow-up
3 months
Authors
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HRT does not improve HRV; confirms lack of autonomic benefit and aligns with absent cardiovascular protection in postmenopausal women.
Does hormone replacement therapy (estradiol alone or with norethisterone) improve 24-hour heart rate variability in healthy postmenopausal women?
Hormone replacement therapy for 3 months does not improve cardiac autonomic modulation as measured by heart rate variability in healthy postmenopausal women, consistent with a lack of cardiovascular protection.
Fernandes et al. (2005) studied this question.
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