Key result
Estrogen replacement therapy significantly decreased the low frequency power portion of heart rate variability to 40.1 nu compared to 54.3 nu in untreated postmenopausal women, indicating a shift toward more beneficial autonomic control.
Why the study?
Does estrogen replacement therapy improve heart rate variability in postmenopausal women?
Population
925 healthy volunteers from Taipei, Taiwan, comprising premenopausal women, postmenopausal women without…
Comparison
Conjugated estrogen or combined hormone… vs Postmenopausal women without hormonal treatment…
Design
Cross-sectional, The group of postmenopausal women was divided randomly into…
Follow-up
at least two consecutive months (for the follow-up study)
Authors
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Should not change practice based on cross-sectional HRV data; leaves open whether estrogen causally improves autonomic function in postmenopausal women.
Cross-Sectional (n=925)
Randomized
No
Does estrogen replacement therapy improve heart rate variability in postmenopausal women?
Absolute Event Rate: 40.1% vs 54.3%
p-value: p=<0.05
Estrogen replacement therapy, but not combined estrogen-progesterone therapy, improves heart rate variability in postmenopausal women, suggesting a restoration of vagal modulation similar to premenopausal levels.
Yang et al. (2013) conducted a cross-sectional in Menopause (n=925). Estrogen replacement therapy vs. No hormonal treatment was evaluated on Low frequency power portion (LF%) of heart rate variability (p=<0.05). Estrogen replacement therapy significantly decreased the low frequency power portion of heart rate variability to 40.1 nu compared to 54.3 nu in untreated postmenopausal women, indicating a shift toward more beneficial autonomic control.
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