April 1, 2007Brazilian Journal of Medical and Biological ResearchOpen Access

Autonomic modulation of heart rate of young and postmenopausal women undergoing estrogen therapy

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Why the study?

Does estrogen therapy improve autonomic control of heart rate in postmenopausal women?

Structured PICO

Does estrogen therapy improve autonomic control of heart rate in postmenopausal women?

Population

37 women: 13 young (24 +/- 2.6 years), 10 postmenopausal undergoing estrogen therapy (53 +/- 4.6 years), and 14 postmenopausal not undergoing estrogen therapy (56 +/- 2.6 years).

Intervention

Estrogen therapy (0.625 mg/day conjugated equine estrogen)

Comparator

Postmenopausal women not undergoing estrogen therapy, and young women

Outcome

Heart rate variability (HRV) analyzed by time (SDNN and rMSSD indices) and frequency domain methods (LF, HF, LF/HF ratio) at rest in supine and sitting positionssurrogate

Estrogen therapy appears to attenuate the age-related decrease in heart rate variability by reducing sympathetic activity in postmenopausal women.

Discussion

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Implication

Estrogen therapy was associated with better autonomic indices; hypothesis-generating and should not change practice without prospective trials.

Cite This Study

Neves et al. (2007) studied this question.

synapsesocial.com/papers/6a7e98a35983bb1e9d4f771e https://doi.org/10.1590/s0100-879x2007000400007

Topics

Women and heart disease

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Implication

Estrogen therapy was associated with better autonomic indices; hypothesis-generating and should not change practice without prospective trials.

Autonomic modulation of heart rate of young and postmenopausal women undergoing estrogen therapy

Structured PICO

Discussion

Implication

Cite This Study

Topics

Autonomic modulation of heart rate of young and postmenopausal women undergoing estrogen therapy

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider