Key result
Medroxyprogesterone acetate (10 mg/day) was statistically equivalent to conjugated equine oestrogen (0.6 mg/day) in controlling daytime hot flushes (0.187 vs 0.363 occurrences/day; P=0.156).
Why the study?
Does medroxyprogesterone acetate reduce hot flushes and night sweats compared to conjugated equine oestrogen in women following premenopausal ovariectomy?
Population
38 healthy menstruating women prior to hysterectomy/ovariectomy for benign disease, mean age 45 (SD 5) years
Comparison
Medroxyprogesterone acetate 10 mg/day oral daily vs Conjugated equine oestrogen 0.6 mg/day oral daily
Design
RCT, randomized parallel group, double-blind
Follow-up
1 year
Authors
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Medroxyprogesterone acetate is equivalent to conjugated equine oestrogen for daytime hot flushes after ovariectomy; confirms both agents as effective in premenopausal women.
RCT (n=38)
Double-blind
Randomized
No
Does medroxyprogesterone acetate reduce hot flushes and night sweats compared to conjugated equine oestrogen in women following premenopausal ovariectomy?
Absolute Event Rate: 0.187% vs 0.363%
p-value: p=0.156
Medroxyprogesterone acetate and conjugated equine oestrogen are equivalent and effective in controlling the number of hot flushes and night sweats immediately following premenopausal ovariectomy.
Avest et al. (2007) conducted an RCT in Hot flushes and night sweats (n=38). Medroxyprogesterone acetate (MPA) vs. Conjugated equine oestrogen (CEE) 0.6 mg/day was evaluated on Mean/day daytime occurrences of hot flushes (p=0.156). Medroxyprogesterone acetate (10 mg/day) was statistically equivalent to conjugated equine oestrogen (0.6 mg/day) in controlling daytime hot flushes (0.187 vs 0.363 occurrences/day; P=0.156).
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