Key result
Menopausal hormone therapy significantly decreased the index S of synchronization between low-frequency oscillations in heart rate variability and photoplethysmographic waveform variability from 39.6% to 21.0% over 6 weeks (P<0.001).
Why the study?
Does menopausal hormone therapy alter cardiovascular autonomic control and sex hormones in perimenopausal women?
Observational (n=70)
No
Does menopausal hormone therapy alter cardiovascular autonomic control and sex hormones in perimenopausal women?
Absolute Event Rate: 21% vs 39.6%
p-value: p=<0.001
Menopausal hormone therapy alters systemic control of circulation (index S) but does not significantly change heart autonomic control as measured by standard HRV indices.
MHT-associated drop in index S should not yet change practice; leaves open effects on autonomic control in perimenopause.
Objective The aim of this study was to assess the dynamical interaction between the cardiovascular autonomic control and sex hormones in perimenopausal women under menopausal hormone therapy (MHT). Patients and methods Seventy women (age: 51.6±2.1 years) were treated with MHT. Standard time and frequency domain measures of heart rate variability (HRV) and index S of synchronization between the slow oscillations in HRV and photoplethysmographic waveform variability were studied during a 6-week treatment with MHT. We assessed also the dynamics of the following sex hormones: estradiol, follicle-stimulating hormone, dehydroepiandrosterone sulfate, and testosterone. Results MHT increased estradiol and decreased follicle-stimulating hormone. Hot flashes and index S were significantly decreased under MHT ( P <0.05). Other autonomic indices were not significantly changed ( P >0.05). Changes of index S did not correlate with changes of sex hormones and hot flushes ( P >0.05). Conclusion The obtained results may indicate the independence of heart autonomic control (assessed by HRV measures) from women’s hormonal status. However, any changes in sex hormones contribute to changes in the systemic control of circulation, which is assessed by index S .
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Kiselev et al. (2018) conducted an observational in Perimenopausal symptoms (n=70). Menopausal hormone therapy (17-β-estradiol and dydrogesterone) vs. Baseline (pre-treatment) was evaluated on Index S of synchronization between low-frequency oscillations in heart rate variability and photoplethysmographic waveform variability (p=<0.001). Menopausal hormone therapy significantly decreased the index S of synchronization between low-frequency oscillations in heart rate variability and photoplethysmographic waveform variability from 39.6% to 21.0% over 6 weeks (P<0.001).
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