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April 19, 2026Cancer Research0 citations

Pan-GATA Molecular Glues for Targeted Degradation of GATA3 in ER+ Breast Cancers

Abstract LB059: Pan-GATA molecular glues as novel tools for targeted degradation of GATA3in ER+breast cancers

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Authors

CFClémentine FéauKGKalyani GampaEJEvan T. Judd

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Overview

Reveals the effectiveness of GATA3 degradation in ER+ breast cancers, suggesting new drug development pathways.

Key Points

  • Investigating the targeted degradation of GATA3 to impede growth in ER-positive breast cancer.
  • Utilized pooled shRNA and CRISPR screens in various cancer cell lines to identify GATA3 dependency.
  • Performed RNA-seq and ChIP-seq analyses to assess gene expression changes post-GATA3 knockdown.
  • Developed small molecule degraders that target GATA3 by forming complexes with CRBN E3 ligase.
  • Inducible knockdown of GATA3 resulted in significant growth inhibition in vitro and in vivo.
  • GATA3 knockdown disrupted ER binding to chromatin, highlighting a synergistic regulatory mechanism.
  • Molecular glue degraders exhibited high efficacy against GATA3 in breast cancer models.

Cite This Study

Féau et al. (2026) studied this question.

synapsesocial.com/papers/69e473de010ef96374d8f963https://doi.org/10.1158/1538-7445.am2026-lb059
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