Direct C–H amination of indoles enabled by tert -butyl chlorosulfonylcarbamate with diisopropylethylamine

Yufeng Lin; Xiaomeng Wang; Xi Zhang; Chunhao Yang

doi:10.1039/d6ob00465b

January 1, 2026Organic & Biomolecular Chemistry

Direct C–H amination of indoles enabled by tert -butyl chlorosulfonylcarbamate with diisopropylethylamine

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Key Points

This research aims to develop a simple and efficient method for synthesizing Boc-protected 2-aminoindoles without a catalyst.
Utilized tert-butyl chlorosulfonylcarbamate as a nitrogen source.
Employed simple indole substrates for the reaction.
Conducted the reaction under straightforward conditions without the need for catalysts.
Achieved successful preparation of Boc-protected 2-aminoindoles.
Demonstrated the feasibility of the method under mild conditions.
Highlight an efficient use of readily available reagents in synthesis.

Implication

A method reports successful C–H amination of indoles, suggesting improved approaches for synthesizing aminoindoles.

Abstract

A catalyst-free method for the preparation of Boc-protected 2-aminoindoles was reported. This protocol features simple indole substrates and a readily available nitrogen source under exceptionally simple reaction conditions.

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Cite This Study

Lin et al. (2026) studied this question.

synapsesocial.com/papers/69e473ff010ef96374d8fb4e https://doi.org/10.1039/d6ob00465b

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Direct C–H amination of indoles enabled by tert -butyl chlorosulfonylcarbamate with diisopropylethylamine

Key Points

Implication

Abstract

Discussion

Cite This Study

Direct C–H amination of indoles enabled by tert -butyl chlorosulfonylcarbamate with diisopropylethylamine

Key Points

Implication

Abstract

Discussion

Cite This Study

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