Key result
Qianyang Yuyin granule reduces blood pressure and cardiac remodeling in hypertensive mice by inhibiting PKM2-mediated glycolysis.
Why the study?
To investigate the effect of Qianyang Yuyin granule on AngII-induced hypertensive cardiac remodeling, focusing on the role of PKM2-mediated glycolysis.
Does Qianyang Yuyin granule improve hypertensive cardiac remodeling in an AngII-induced mouse model?
Does Qianyang Yuyin granule improve hypertensive cardiac remodeling in an AngII-induced mouse model?
Qianyang Yuyin granule attenuates hypertensive cardiac remodeling in mice, potentially by modulating the HIF-1α/PKM2-mediated glycolytic pathway.
Answers are grounded in this paper and cite their sources.
Should not yet change practice in hypertensive heart disease; hypothesis-generating for QYYY and needs clinical trials.
OBJECTIVE: To investigate the effect of Qianyang Yuyin granule ( QYYY) on AngII-induced hypertensive cardiac remodeling, focusing on the role of pyruvate kinase isozyme M2 (PKM2) mediated glycolysis.METHODS: A hypertensive mouse model was established in male C57BL/6 mice by continuous infusion of angiotensin II (AngII; 1000 ngkgmin).Mice were administered varying doses of QYYY, with sacubitril/ valsartan (Sac/Val) serving as the positive control.Parameters evaluated included blood pressure, cardiac function, hypertrophy, fibrosis, inflammation, and apoptosis.The metabolic profile of myocardial tissue was analyzed using ultra performance liquid chromatography tandem mass spectrometry.Additionally, the involvement of the hypoxia-inducible factor 1-alpha (HIF-1)/PKM2 signaling pathway was examined by Western blotting and immunohistochemistry.RESULTS: QYYY significantly lowered blood pressure, attenuated cardiac hypertrophy and fibrosis, reduced serum levels of inflammatory factors tumor necrosis factor- and tumor necrosis factor-, and decreased activation of phospho-NF-kappa B p65 pathway in cardiac tissue of hypertensive mice.Metabolomic analysis indicated that QYYY ameliorated cardiometabolic dysfunction, primarily associated with energy and amino acid metabolism, involving modulation of the HIF-1/PKM2-mediated glycolytic pathway.CONCLUSION: QYYY effectively improves cardiac remodeling in hypertensive mice, potentially through inhibition of the PKM2-mediated glycolytic signaling pathway.
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Sun et al. (2025) studied this question. Qianyang Yuyin granule significantly lowered blood pressure and attenuated cardiac hypertrophy, fibrosis, and inflammation in hypertensive mice by inhibiting PKM2-mediated glycolysis.
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