Exploring the anti-cancer potential of gut microbiota-derived short-chain fatty acids in ovarian cancer: a comparative analysis of sodium butyrate and sodium propionate on proliferation, cell cycle, and apoptosis
Comparative analysis reveals sodium butyrate significantly reduces ovarian cancer cell proliferation and induces apoptosis, highlighting its potential as a therapy.
Key Points
This study investigates the anti-cancer effects of sodium butyrate and sodium propionate on ovarian cancer cell lines SKOV-3 and PA-1.
In vitro comparative analysis of sodium butyrate and sodium propionate on two ovarian cancer cell lines.
Assessment of cell proliferation, colony formation, and spheroid formation post-treatment.
Analysis of cell cycle effects and apoptosis induction via checkpoint proteins and apoptotic markers.
Both sodium butyrate and sodium propionate reduced proliferation and colony formation in a dose- and time-dependent manner.
Sodium butyrate showed greater potency with significantly lower IC₅₀ values compared to sodium propionate.
Both treatments induced G2/M phase cell cycle arrest and increased late apoptosis, with sodium butyrate having a more pronounced effect.