Key result
A structured digital health intervention improves medication adherence scores by 1.8 points versus standard care.
Why the study?
Hypertension control is poor in Uzbekistan largely due to medication non-adherence amid urbanization and limited resources.
Does a structured digital health intervention improve medication adherence in adults with essential hypertension?
RCT (n=320)
1:1
Yes
Does a structured digital health intervention improve medication adherence in adults with essential hypertension?
A culturally tailored digital health intervention significantly improved medication adherence and blood pressure control in hypertensive patients in Uzbekistan.
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Warrants DHI integration in resource-limited primary care; extends RCT evidence for digital adherence tools to urbanizing middle-income settings.
Hypertension affects over 70% of diagnosed patients in Uzbekistan with poor control, largely due to medication non-adherence amid urbanization and limited resources. This trial evaluated a structured digital health intervention (DHI) a multilingual Android app with reminders, education, and gamification on adherence in primary care settings. In this prospective RCT across three Tashkent clinics (March 2024–December 2025), 320 adults (40–75 years) with essential hypertension (BP ≥140/90 mmHg on monotherapy) were randomized 1:1 to DHI plus standard care or standard care alone. Primary outcome: 12-month adherence (MMAS-8 score). Secondaries: BP control, quality of life (EQ-5D-5L), utilization. Analysis: intention-to-treat mixed models (P<0.05). Baseline balanced (mean age 58 years, MMAS-8 ~5). DHI boosted adherence (7.2 vs. 5.4; mean diff 1.8, 95% CI 1.5–2.1, P<0.001; high adherence 89% vs. 58%). BP fell more (SBP -14.2 mmHg, 78.7% controlled vs. 41.3%, OR 5.6; both P<0.001). Utilization dropped (visits RR 0.62), EQ-5D +0.10 (P<0.001). Engagement high (85% reminders).This culturally tailored DHI markedly improved adherence, BP, and outcomes in Uzbekistan, supporting scalable digital integration for hypertension management.
Zarnigor et al. (2026) conducted an RCT in essential hypertension (n=320). structured digital health intervention (DHI) plus standard care vs. standard care alone was evaluated on 12-month adherence (MMAS-8 score) (mean diff 1.8, 95% CI 1.5-2.1, p=<0.001). A structured digital health intervention significantly improved 12-month medication adherence compared to standard care (MMAS-8 score 7.2 vs. 5.4; mean diff 1.8, 95% CI 1.5–2.1, P<0.001).
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