What question did this study set out to answer?

To determine whether circulating mitochondrial N-formyl peptides (mtFPs) contribute to secondary nosocomial infection susceptibility in patients experiencing septic shock.

April 22, 2021Proceedings of the National Academy of SciencesOpen Access

Circulating mitochondrialN-formyl peptides contribute to secondary nosocomial infection in patients with septic shock

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To determine whether circulating mitochondrial N-formyl peptides (mtFPs) contribute to secondary nosocomial infection susceptibility in patients experiencing septic shock.
Measured circulating levels of mitochondrial N-formyl peptides, focusing on nicotinamide adenine dinucleotide dehydrogenase subunit-6 (ND6), in patients with septic shock.
Evaluated the impact of mtFPs on polymorphonuclear leukocyte (PMN) chemotaxis and formyl peptide receptor-1 occupancy.
Elevated plasma levels of nicotinamide adenine dinucleotide dehydrogenase subunit-6 independently associated with secondary nosocomial infection development in septic shock.
Mitochondrial peptide occupancy of formyl peptide receptor-1 suppressed polymorphonuclear leukocyte chemotaxis, precipitating chemotactic anergy and infection susceptibility.

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Implication

Clinical study demonstrates that circulating mitochondrial peptides impair neutrophil chemotaxis in septic shock, indicating a driver of secondary hospital-acquired infections.

Cite This Study

Kwon et al. (2021) studied this question.

synapsesocial.com/papers/69e5ebd0bde0d10efc13c574 https://doi.org/10.1073/pnas.2018538118

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Implication

Clinical study demonstrates that circulating mitochondrial peptides impair neutrophil chemotaxis in septic shock, indicating a driver of secondary hospital-acquired infections.

Circulating mitochondrialN-formyl peptides contribute to secondary nosocomial infection in patients with septic shock

Key Points

Discussion

Implication

Cite This Study

Circulating mitochondrialN-formyl peptides contribute to secondary nosocomial infection in patients with septic shock

Key Points

Discussion

Implication

Cite This Study

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