October 31, 2006Proceedings of the National Academy of Sciences

Cardiac myosin binding protein c phosphorylation is cardioprotective

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Why the study?

Does constitutive phosphorylation of cMyBP-C protect the myocardium from ischemic injury in a transgenic mouse model?

Structured PICO

Does constitutive phosphorylation of cMyBP-C protect the myocardium from ischemic injury in a transgenic mouse model?

Population

Transgenic mice with cardiac-specific expression of a cMyBP-C mimicking constitutive phosphorylation (cMyBP-C(AllP+)) bred into a cMyBP-C null background (cMyBP-C((t/t)))

Intervention

Genetic mutation of three cMyBP-C phosphorylation sites (Ser-273, Ser-282, and Ser-302) to aspartic acid to mimic constitutive phosphorylation

Comparator

cMyBP-C null background

Outcome

Resistance to ischemia-reperfusion injury, sarcomere ultrastructure, and interaction with myosin heavy chainsurrogate

Constitutive phosphorylation of cMyBP-C maintains thick filament spacing and protects the myocardium from ischemia-reperfusion injury in a mouse model.

Discussion

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Implication

May protect against ischemia-reperfusion injury in mice; leaves open translation to human disease or therapy.

Cite This Study

Sadayappan et al. (2006) studied this question.

synapsesocial.com/papers/69e6bf58d80363863fe6e78c https://doi.org/10.1073/pnas.0607069103

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Cardiac myosin binding protein c phosphorylation is cardioprotective

Structured PICO

Discussion

Implication

Cite This Study

Cardiac myosin binding protein c phosphorylation is cardioprotective

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider