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April 21, 2026Frontiers in Bioengineering and BiotechnologyOpen Access

Integrating cells, scaffolds, and molecular regulation: a mechanobiological and translational review of bioengineering therapies for intervertebral disc degeneration

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Authors

WHWang HaoShandong University of Traditional Chinese MedicineCRChen RenchangShandong University of Traditional Chinese MedicineXWXia WaAnyang Hospital of Traditional Chinese Medicine

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Implication

This review highlights bioengineering therapies addressing intervertebral disc degeneration, suggesting potential solutions for pain relief and disc function restoration.

Key Points

  • The aim is to review bioengineering therapies for intervertebral disc degeneration and their potential to restore disc structure and function.
  • Reviewed current bioengineering approaches including cell therapy and tissue-engineered scaffolds.
  • Discussed gene therapy and mechanobiological concepts in the context of disc health.
  • Evaluated the effectiveness of interventions through animal models and early clinical trials.
  • Bioengineering therapies show promise in reducing pain and restoring disc height.
  • Multidisciplinary approaches are essential for successful clinical implementation.
  • Challenges include low cell survival rates and safety of gene delivery methods.

Cite This Study

Hao et al. (2026) studied this question.

synapsesocial.com/papers/69e7132bcb99343efc98cf17https://doi.org/10.3389/fbioe.2026.1803183
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  4. 4Tissue-Engineered Injectable Gelatin–Methacryloyl Hydrogel-Based Adjunctive Therapy for Intervertebral Disc Degeneration2023 · 30 citations
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