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July 25, 2025World Journal of Stem Cells

Therapeutic strategies for intervertebral disc degeneration: Extracellular vesicles and microRNAs derived from mesenchymal stem cells

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Authors

YLYoung‐Ju LimMSMin‐Soo SeoSPSang‐Bum Park

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Overview

Therapeutic agents enhance regeneration and modify inflammation in intervertebral disc degeneration, suggesting new treatment pathways.

Key Points

  • Intervertebral disc degeneration results from an imbalance leading to matrix changes and cell loss.
  • Extracellular vesicles derived from mesenchymal stem cells show potential for regeneration and anti-inflammation.
  • Current treatments like surgery and drugs do not effectively reverse disc degeneration.
  • Optimizing cell culture for therapeutic usage of extracellular vesicles may enhance their clinical effectiveness.

Cite This Study

Lim et al. (2025) studied this question.

synapsesocial.com/papers/689a0627e6551bb0af8ce1a5https://doi.org/10.4252/wjsc.v17.i7.107212
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