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June 14, 2026Nano ResearchOpen Access

Exosomes as therapeutic delivery vehicles for intervertebral disc degeneration: Mechanisms and applications

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Authors

TXTao XuMCMeng ChengRDRongpeng Dong

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Implication

Review shows exosomes may treat intervertebral disc degeneration, highlighting their potential in regenerative therapies.

Key Points

  • This paper aims to explore the role of exosomes as delivery vehicles in treating intervertebral disc degeneration.
  • Comprehensive review of biological characteristics of exosomes, including sources and secretion mechanisms.
  • Discussion of mechanisms of action and signaling pathways of exosomes from different sources.
  • Identification of challenges and future research directions regarding exosome applications.
  • Exosomes demonstrate low immunogenicity and toxicity, making them suitable for medical applications.
  • Exosomes can effectively cross biological barriers and deliver therapeutic agents to target sites.
  • Regenerative therapies involving exosomes are advancing rapidly, suggesting promising outcomes for intervertebral disc degeneration.

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6a2e4687b1cc60ccdea8b4c2https://doi.org/10.26599/nr.2026.94908923
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exosome Therapy: A Promising Avenue for Treating Intervertebral Disc Degeneration2025 · 7 citations
  2. 2Therapeutic strategies for intervertebral disc degeneration: Extracellular vesicles and microRNAs derived from mesenchymal stem cells2025 · 4 citations
  3. 3The promising potential of small extracellular vesicles in the field of intervertebral disc repair - a comprehensive meta-analysis2026
  4. 4A Challenge-Oriented Review of Delivery Systems for Cell and Gene Therapies in Intervertebral Disc Degeneration2026
  5. 5Innovative strategies in combating intervertebral disc degeneration: pathological mechanisms and biomaterial advancements2025 · 12 citations