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May 22, 2026BioengineeringOpen Access

A Challenge-Oriented Review of Delivery Systems for Cell and Gene Therapies in Intervertebral Disc Degeneration

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Authors

WWW WuUnion HospitalZCZhangrong ChengUnion HospitalHGHaiyang GaoUnion Hospital

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Implication

Review highlights gene and cell therapy delivery challenges in intervertebral disc degeneration, suggesting novel solutions.

Key Points

  • This review aims to analyze the challenges and solutions in delivering cell and gene therapies for intervertebral disc degeneration.
  • Reviewed the intervertebral disc structure and its microenvironment
  • Conducted a comparative analysis of various delivery platforms
  • Examined fabrication technologies and material considerations affecting performance
  • Identified key delivery challenges: mechanical protection, retention, targeted delivery, controlled release, and metabolic support.
  • Highlighted the need for bioengineered systems to improve therapy efficacy.
  • Proposed emerging strategies like gene-cell combination therapy to enhance clinical application.

Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/6a0ff312d674f7c03778b8a0https://doi.org/10.3390/bioengineering13050566
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Also Consider

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  1. 1Surviving the Nucleus Pulposus Desert: Next‐Generation Strategies for Intervertebral Disc Cell Therapy2026
  2. 2Innovative strategies in combating intervertebral disc degeneration: pathological mechanisms and biomaterial advancements.2025 · 12 citations
  3. 3Stimuli-Responsive Delivery Systems for Intervertebral Disc Degeneration2024 · 26 citations
  4. 4Advances and mechanisms of hydrogel-based interventions for intervertebral disc degeneration repair2026
  5. 5Integrating cells, scaffolds, and molecular regulation: a mechanobiological and translational review of bioengineering therapies for intervertebral disc degeneration2026 · 1 citations