What question did this study set out to answer?

The study aims to assess how preoperative systemic inflammatory markers influence neoadjuvant chemotherapy selection and their prognostic value in advanced serous epithelial ovarian cancer.

April 22, 2026Irish Journal of Medical Science (1971 -)Open Access

Systemic inflammatory markers are associated with neoadjuvant chemotherapy selection but not survival in advanced serous epithelial ovarian cancer

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Authors

YYYakup Yalcin KOKemal OzerkanBursa Uludağ Üni̇versi̇tesi̇

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Implication

Retrospective cohort study evaluates inflammatory markers' association with chemotherapy selection in advanced ovarian cancer, indicating their role in treatment decisions.

Key Points

The study aims to assess how preoperative systemic inflammatory markers influence neoadjuvant chemotherapy selection and their prognostic value in advanced serous epithelial ovarian cancer.
Conducted a retrospective cohort study with patients having FIGO stage III–IV high-grade serous epithelial ovarian cancer.
Calculated preoperative inflammatory markers (NLR, PLR, SII) and used median cut-offs for analysis.
Performed multivariable analyses to evaluate associations with chemotherapy selection and survival outcomes.
Patients selected for NACT had significantly higher preoperative NLR, PLR, and SII values.
High NLR and SII were independently associated with increased likelihood of NACT selection.
None of the inflammatory markers were associated with prognosis; NACT was linked to lower overall survival and progression-free survival.

Cite This Study

Yalcin et al. (2026) studied this question.

synapsesocial.com/papers/69e864866e0dea528dde95b5 https://doi.org/10.1007/s11845-026-04407-x

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Implication

Retrospective cohort study evaluates inflammatory markers' association with chemotherapy selection in advanced ovarian cancer, indicating their role in treatment decisions.

Systemic inflammatory markers are associated with neoadjuvant chemotherapy selection but not survival in advanced serous epithelial ovarian cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Systemic inflammatory markers are associated with neoadjuvant chemotherapy selection but not survival in advanced serous epithelial ovarian cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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