What is the clinical evidence from this study?

Study design: Cohort. Population: New-onset stroke (n=4823). Intervention: High TyHGB index pattern vs. Low TyHGB index pattern. Primary outcome: New-onset stroke (HR 1.33, 95% CI 1.01-1.78).

What does this research mean for the field?

A high longitudinal pattern of the TyHGB index significantly increases the risk of new-onset stroke compared to a low pattern, providing incremental predictive value over the traditional TyG index. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the association between longitudinal trajectory patterns and cumulative burden of the novel triglyceride-high-density lipoprotein-glucose-body (TyHGB) index and the risk of new-onset stroke.

April 22, 2026Lipids in Health and DiseaseOpen Access

Association between the triglyceride-high-density lipoprotein-glucose-body index and new-onset stroke risk: a prospective cohort study

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Key result

High longitudinal TyHGB index pattern linked to ~33% higher risk of new-onset stroke versus low pattern.

HR 1.33
95% CI 1.01-1.78
n=4,823

Why the study?

The association between longitudinal patterns of the novel TyHGB index, which integrates triglycerides, fasting blood glucose, HDL-C, and BMI, and new-onset stroke risk was unclear.

Does an elevated TyHGB index increase the risk of new-onset stroke in adults aged 45 and older?

Population

4,823 participants free of stroke at baseline

Comparison

High and Medium vs Low longitudinal patterns of the TyHGB index

Design

Prospective cohort study

Follow-up

5-year

Authors

ALAoMen LuGeneral / Preventive / Lipids QXQian XuHebei North University

Discussion

Member takes

Implication

Should not yet change practice in IR-driven stroke prevention; leaves open TyHGB's incremental value beyond TyG pending validation.

Key Points

To evaluate the association between longitudinal trajectory patterns and cumulative burden of the novel triglyceride-high-density lipoprotein-glucose-body (TyHGB) index and the risk of new-onset stroke.
Analyzed 4,823 participants free of stroke at baseline from the China Health and Retirement Longitudinal Study (CHARLS, 2011–2020) over a 5-year follow-up.
Identified longitudinal TyHGB trajectory patterns using K-means clustering and calculated hazard ratios using multivariable Cox proportional hazards models.
Modeled non-linear dose-response relationships using restricted cubic splines and compared discrimination against the traditional TyG index using time-dependent ROC curves.
In fully adjusted models, participants in the Medium (HR = 1.34, 95% CI: 1.07–1.67, P < 0.001) and High (HR = 1.33, 95% CI: 1.01–1.78, P = 0.039) TyHGB patterns had significantly greater stroke risk compared to the Low pattern.
Cumulative TyHGB exhibited a non-linear relationship with stroke risk (P-non-linear < 0.05) with an inflection threshold at 25.76, while baseline TyHGB modestly improved 5-year stroke prediction over the TyG index (AUC: 0.591 vs. 0.574).

Study Design

Type

Cohort (n=4,823)

Multicenter

Yes

Structured PICO

Does an elevated TyHGB index increase the risk of new-onset stroke in adults aged 45 and older?

Population

4,823 adults aged 45 and older free of stroke at baseline from the China Health and Retirement Longitudinal Study (CHARLS), mean age 58.5, 56.4% male, China-based.

Intervention

High and Medium longitudinal patterns, cumulative burden, and elevated baseline levels of the TyHGB (triglyceride-high-density lipoprotein-glucose-body) index

Comparator

Low longitudinal pattern or lower tertiles of the TyHGB index

Outcome

New-onset stroke (incident stroke cases) during 5-year follow-uphard clinical

Main Result

Effect estimate: HR 1.33 (95% CI 1.01-1.78)

Absolute Event Rate: 10.2% vs 7%

Long-term elevated patterns and cumulative burden of the TyHGB index are independent risk factors for new-onset stroke, offering modest incremental predictive value over the traditional TyG index.

Limitations

Exact date of stroke onset was not always available, resulting in interval-censored data

Cite This Study

Lu et al. (2026) conducted a cohort in New-onset stroke (n=4,823). High TyHGB index pattern vs. Low TyHGB index pattern was evaluated on New-onset stroke (HR 1.33, 95% CI 1.01-1.78). A high longitudinal pattern of the TyHGB index significantly increased the risk of new-onset stroke compared to a low pattern (HR 1.33).

synapsesocial.com/papers/69e864c46e0dea528dde96f5 https://doi.org/10.1186/s12944-026-02953-y

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Association between the triglyceride-high-density lipoprotein-glucose-body index and new-onset stroke risk: a prospective cohort study

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Association between the triglyceride-high-density lipoprotein-glucose-body index and new-onset stroke risk: a prospective cohort study

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider