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This research aims to understand how stem-like T cells are maintained in cancer and their role under PD1 blockade.

April 22, 2026Molecular OncologyOpen Access

Checkpoint blockade and the stem‐like T cell trade‐off

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This research aims to understand how stem-like T cells are maintained in cancer and their role under PD1 blockade.
Used high-dimensional 3D-imaging and immunological profiling in murine cancer models
Defined the niche of stem-like T cells in tumor-draining lymph nodes
Investigated the influence of conventional type 1 dendritic cells and PD1 signaling on T cell populations.
Identified a critical role for cDC1s in sustaining stem-like T cell populations
Disruption of PD1 signaling increased effector T cell numbers but reduced stem-like T cell survival
Revealed potential vulnerabilities in immune checkpoint blockade when tumors persist post-treatment.

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Research uncovers the role of PD1 pathway in regulating stem-like T cells, suggesting implications for cancer treatment strategies.

Mazet et al. (2026) studied this question.

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