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April 22, 2026Journal of Inflammation ResearchOpen Access

The Mediating Role of Inflammation in the Association Between NHHR and Pelvic Inflammatory Disease: A Case-Control Study Based on Machine Learning

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Authors

YDYanan DuanYSYu SuYPYiqing Peng

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Overview

This case-control study explores NHHR's link to PID, with inflammation mediating the association.

Key Points

  • This study investigates the relationship between NHHR and pelvic inflammatory disease (PID), focusing on the mediating role of inflammation.
  • Conducted a retrospective case-control study with 2,247 women using surgical and clinical records.
  • Utilized LASSO regression for predictor identification and multivariate logistic regression for analysis.
  • Developed a prediction model for PID risk and assessed through mediation analysis involving WBC count.
  • Higher NHHR was significantly associated with PID (OR = 1.39, 95% CI = 1.16–1.66).
  • WBC count partially mediated 19.26% of the NHHR–PID relationship.
  • The prediction model showed strong discrimination with AUCs of 0.825 (training) and 0.819 (validation).

Cite This Study

Duan et al. (2026) studied this question.

synapsesocial.com/papers/69e865926e0dea528ddea081https://doi.org/10.2147/jir.s527740
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between cardiovascular health and pelvic inflammatory disease: Analyses of the NHANES 2015 to 20182024 · 1 citations
  2. 2Association between high-density lipoprotein cholesterol-related inflammatory markers and female infertility: a cross-sectional analysis from the National Health and Nutrition Examination Survey (NHANES 2013–2018)2025
  3. 3U-shaped association between the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol and risk of cholelithiasis: a cohort study2025 · 1 citations
  4. 4Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and risk of endometrial cancer among US adults: A population-based study.2024
  5. 5Association Between Dietary Index for Gut Microbiota and the Risk of Pelvic Inflammatory Disease: Mediating Role of Anti‐ and Pro‐Inflammatory Dietary Patterns2026 · 2 citations