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April 22, 2026Open Access

Conditioned medium from mesenchymal stem cells: Towards skin tissue engineering and wound healing.

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Authors

NNNahid NasiriPHParnia HemmatiSTSeyed Mehdi Tabaie

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Implication

This review examines the role of MSC-derived conditioned medium in wound healing, highlighting its therapeutic potential.

Key Points

  • This review explores the therapeutic effects of conditioned medium from mesenchymal stem cells on skin regeneration and wound healing.
  • Comprehensive review of preclinical and clinical studies on MSC-derived conditioned medium.
  • Evaluation of key components such as growth factors, cytokines, and extracellular vesicles.
  • Discussion of challenges related to standardization and regulatory approval.
  • MSCs enhance wound healing through their paracrine activity in conditioned medium.
  • Key components like cytokines and growth factors promote inflammation modulation and collagen synthesis.
  • Therapeutic use of MSC-CM shows potential in treating acute and chronic wounds, including diabetic ulcers.

Cite This Study

Nasiri et al. (2026) studied this question.

synapsesocial.com/papers/69e865b56e0dea528ddea26ehttps://doi.org/10.22038/ijbms.2025.88552.19121
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Therapeutic Potential of MSC-conditioned Medium: A Multifactorial Approach to Enhance Wound Healing2024 · 1 citations
  2. 2Accelerating Wound Repair: The Multifaceted Role of Mesenchymal Stem Cells2024
  3. 3The Role and Prospects of Mesenchymal Stem Cells in Skin Repair and Regeneration2024 · 70 citations
  4. 4Mesenchymal stem cell therapy for skin repair and rejuvenation2026
  5. 5Role of mesenchymal stem cell conditioned medium on wound healing using a developed 3D skin model2024 · 6 citations