Delta opioid peptide (D-Ala2, D-Leu5)-enkephalin (DADLE) mitigates myocardial ischemia-reperfusion injury by inhibiting the TRAF6/NF-κB/NLRP3 pathway.

Key Points

• To investigate the protective effects of DADLE on myocardial ischemia-reperfusion injury and explore the underlying mechanisms.
• Administered DADLE at a dosage of 0.5 mg/kg in an animal model of myocardial ischemia-reperfusion injury.
• Analyzed changes in the TRAF6/NF-κB/NLRP3 signaling pathway post-treatment.
• DADLE significantly improved outcomes in myocardial ischemia-reperfusion injury.
• The dosage of 0.5 mg/kg showed the greatest protective effect.
• Activation of the TRAF6/NF-κB/NLRP3 pathway was inhibited by DADLE.