Why the study?
Do fitness and physical activity reduce incident cardiovascular disease in the general population and those with elevated genetic risk?
Do fitness and physical activity reduce incident cardiovascular disease in the general population and those with elevated genetic risk?
Higher levels of fitness and physical activity are associated with a lower risk of incident cardiovascular disease, even among individuals with elevated genetic risk.
May support activity promotion irrespective of genetic risk; extends observational data to high-genetic-risk groups but leaves causality open.
Fitness and physical activity demonstrated inverse associations with incident cardiovascular disease in the general population, as well as in individuals with elevated genetic risk for these diseases.
No takes yet. Share an insight, caveat, or question.
Tikkanen et al. (2018) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: