High-dose intravenous steroid therapy led to rapid hemodynamic improvement and recovery of left ventricular ejection fraction from 25% to 60% in a patient with fulminant lupus myocarditis.
Case Report (n=1)
No
Does high-dose steroid therapy improve cardiac function in fulminant lupus myocarditis?
Early recognition and prompt initiation of high-dose steroid therapy in fulminant lupus myocarditis can lead to rapid recovery of cardiac function without the need for mechanical circulatory support.
Lupus myocarditis (LM) is a rare but potentially life-threatening manifestation of systemic lupus erythematosus. We report the case of a 36-year-old woman who presented with fulminant heart failure refractory to standard therapy. Concomitant nephrotic syndrome, hypocomplementemia, and positive anti-double-stranded DNA antibodies supported the diagnosis of LM. Given her rapid hemodynamic deterioration, high-dose intravenous steroid therapy was promptly initiated, leading to a rapid recovery of her cardiac function without mechanical circulatory support. An endomyocardial biopsy demonstrated mononuclear inflammatory cell infiltration and mild fibrosis, consistent with LM, with prominent tenascin-C deposition.
Morita et al. (Thu,) conducted a case report in Fulminant Lupus Myocarditis / Systemic Lupus Erythematosus (n=1). High-dose steroid therapy (methylprednisolone) was evaluated on Left ventricular ejection fraction (LVEF) recovery. High-dose intravenous steroid therapy led to rapid hemodynamic improvement and recovery of left ventricular ejection fraction from 25% to 60% in a patient with fulminant lupus myocarditis.
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