Efficacy of probiotics in vancomycin-resistant enterococci decolonization: A meta-analysis of randomized clinical trials

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This meta-analysis aims to evaluate the efficacy of probiotics in decolonizing vancomycin-resistant enterococci (VRE) through subgroup analyses.
Systematic review of human trials assessing probiotics for VRE decolonization from databases like PubMed and Embase.
Subgroup analyses stratified by treatment duration, probiotic strain, and patient age were conducted.
Effectiveness was quantified using odds ratios (ORs) derived from a random-effects model.
Probiotics significantly reduced VRE colonization overall (OR: 5.70, p = 0.02).
Lactobacillus rhamnosus GG (LGG) showed stronger effectiveness than other strains (OR: 7.22, p = 0.02).
Probiotics effectively decolonized VRE in pediatric patients (OR: 7.17, p = 0.0005) but had inconsistent effects in adults.

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Meta-analysis reveals probiotics may decolonize vancomycin-resistant enterococci, especially in children, suggesting potential treatments.

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Fan et al. (2026) studied this question.

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