Deep brain stimulation in VPS13C-associated Parkinson’s disease: a longitudinal case study

Key Points

• This research aims to assess the outcomes of deep brain stimulation in individuals with VPS13C-associated Parkinson’s disease.
• Longitudinal case study design
• Assessment of motor, cognitive, and psychiatric changes after DBS
• Evaluation of cardiac MIBG uptake over 7 years
• Initial improvement in symptoms after STN-DBS, followed by rapid decline
• Significant deterioration in motor and cognitive functions
• Cardiac MIBG changed from normal to signs of denervation over 7 years