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April 15, 2026Neurologia i Neurochirurgia Polska

Deep brain stimulation or best medical treatment for Parkinson’s disease patients: 36-month longitudinal neuropsychological and motor assessment — a prospective case-control study

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Authors

SSStanisław SzlufikKDKarolina Duszyńska-WąsAKAleksandra Koźmińska

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Overview

Prospective case-control study compares cognitive and motor outcomes in Parkinson’s disease patients, suggesting limited cognitive benefits from stimulation.

Key Points

  • This research examines the effects of deep brain stimulation compared to best medical treatment on cognitive and motor functions in Parkinson's disease patients.
  • Prospective case-control design
  • Longitudinal assessment over 36 months
  • Comparison of cognitive and motor outcomes between DBS STN and medical treatment groups
  • Use of UPDRS III to measure motor severity
  • DBS STN did not show significant improvements in cognitive performance compared to medical treatment
  • Active DBS STN improved motor symptoms but could not reduce worsening of OFF-motor severity
  • Motor symptom progression was similar between both treatment groups over the study period

Cite This Study

Szlufik et al. (2026) studied this question.

synapsesocial.com/papers/69df2ae6e4eeef8a2a6afd0ahttps://doi.org/10.5603/pjnns.107017
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neuropsychological Outcomes of Long-Term STN-DBS in Parkinson's Disease: A Multidomain Study in a Turkish Cohort2026
  2. 2Clinical and Brain Morphometry Predictors of Deep Brain Stimulation Outcome in Parkinson’s Disease2024 · 3 citations
  3. 3Five-Year Outcomes from Deep Brain Stimulation of the Subthalamic Nucleus for Parkinson Disease2025 · 23 citations
  4. 4Triple perspective: assessing deep brain stimulation outcomes in Parkinson's disease2025 · 1 citations
  5. 5Long-term outcomes of subthalamic nucleus deep brain stimulation for Parkinson’s disease in Singapore2024 · 3 citations