Answers are grounded in this paper and cite their sources.
Lab experiments demonstrate improved thioester hydrolysis in peptides using 2-mercaptophenylboronic acid, suggesting a more effective method.
Herein, we demonstrate that 2-mercaptophenylboronic acid promotes the hydrolysis of peptide alkyl thioesters via thiol-thioester exchange to form a reactive aryl thioester intermediate, followed by borate-assisted hydrolysis of the intermediate....
No takes yet. Share an insight, caveat, or question.
Sato et al. (2025) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: