Dual Cross-linked Biodegradable Polyelectrolyte Hydrogel Actuator for Bi-Directional pH-Responsive Drug Release

Govind Choudhary; Soni Jadoun; Komal Rani; Aashish Sharma; Manikrishna Lakavathu

doi:10.1039/d6pm00077k

January 1, 2026RSC PharmaceuticsOpen Access

Dual Cross-linked Biodegradable Polyelectrolyte Hydrogel Actuator for Bi-Directional pH-Responsive Drug Release

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Key Points

The aim is to develop a biodegradable hydrogel that releases drugs in response to pH changes.
Developed a dual cross-linked hydrogel using gelatin and carboxymethyl cellulose (CMC).
Evaluated pH sensitivity and drug release capabilities of the hydrogel.
The hydrogel exhibited bi-directional pH-responsiveness.
Controlled drug release was achieved at different pH levels.

Implication

This research demonstrates bi-directional pH-responsive drug release using a dual cross-linked hydrogel, indicating potential for targeted therapies.

Abstract

Here, we present dual cross-linked hydrogel with bi-directional pH sensitivity for controlled drug release. The hydrogel was strategically developed with oppositely charged polyelectrolytes namely; gelatin and carboxymethyl cellulose (CMC). This...

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Cite This Study

Choudhary et al. (2026) studied this question.

synapsesocial.com/papers/69e9b8d485696592c86ebdee https://doi.org/10.1039/d6pm00077k

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Dual Cross-linked Biodegradable Polyelectrolyte Hydrogel Actuator for Bi-Directional pH-Responsive Drug Release

Key Points

Implication

Abstract

Discussion

Cite This Study

Dual Cross-linked Biodegradable Polyelectrolyte Hydrogel Actuator for Bi-Directional pH-Responsive Drug Release

Key Points

Implication

Abstract

Discussion

Cite This Study

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