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April 23, 2026Journal of the American Academy of Orthopaedic Surgeons

The Influence of Peripheral Artery Disease on Postoperative Complications Following Open Reduction and Internal Fixation for Ankle Fractures

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Authors

TSTarun R. SontamThe University of Texas Southwestern Medical CenterSTSri TummalaBaylor University Medical CenterMMMehul MittalNorthwestern University

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Implication

Evaluates postoperative complications in patients with peripheral artery disease undergoing ankle fracture fixation, suggesting increased risks.

Key Points

  • Evaluate the impact of peripheral artery disease on postoperative complications following ankle open reduction and internal fixation.
  • Queried TriNetX Research Network for patients undergoing isolated ankle ORIF.
  • Patients classified with or without PAD based on prior diagnosis within 6 months.
  • Propensity score matching used to balance demographics and comorbidities.
  • At 90 days, PAD patients had higher rates of surgical site infection (5.5% vs 2.0%) and wound disruption (10.2% vs 3.9%).
  • At 2 years, PAD was linked to higher risks of nonunion (RR 3.07) and chronic osteomyelitis (RR 8.42).
  • Increased risks of implant infection (RR 3.19) and below-knee amputation (RR 10.5) were observed.

Cite This Study

Sontam et al. (2026) studied this question.

synapsesocial.com/papers/69e9bb2285696592c86ecf1ehttps://doi.org/10.5435/jaaos-d-25-01630
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Significant prevalence of peripheral artery disease in patients with disturbed wound healing following elective foot and ankle surgery: Results from the ABI-PRIORY (ABI as a PRedictor of Impaired wound healing after ORthopedic surgerY) trial2019 · 22 citations
  2. 2Complication Rates Following Open Reduction and Internal Fixation of Ankle Fractures2009 · 475 citations
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  5. 5Health Disparities in Peripheral Artery Disease: A Scientific Statement From the American Heart Association2023 · 177 citations