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Research demonstrates enhanced protein absorption in the intestine, suggesting a novel food-grade strategy for better nutrition.
A natural metabolite-based deep eutectic system composed of betaine and lactic acid (BL-DES) was developed as a food-grade strategy to enhance intestinal absorption of proteins. Insulin was selected as a model protein for convenient and reliable assessment of intestinal absorption. BL-DES reduced the viscosity of simulated intestinal mucus and increased insulin permeability through the mucus layer. Jejunal administration of insulin@BL-DES showed a significant hypoglycemic effect. Hematological, cellular, and histological evaluations confirmed the favorable biocompatibility of BL-DES. Mechanistic investigations revealed that BL-DES promotes paracellular transport through reversible opening of tight junctions.
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Di et al. (2026) studied this question.
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