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April 23, 2026Biomedical Chromatography

From Chemical Discrepancy to Mechanistic Insight: UPLC‐MS, Bioinformatics, and In Vivo Studies on the Anti‐Brain Aging Effects of Polygalae Radix and Its Processed Products

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Authors

JFJiaqi FanLiaoning University of Traditional Chinese MedicineGLGuimei LinShandong UniversityHLHongye LiLiaoning University of Traditional Chinese Medicine

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Implication

Reveals the mechanisms behind anti-brain aging effects in traditional herbal ingredients, suggesting clinical benefits.

Key Points

  • The aim is to investigate the brain-penetrating components and mechanisms of Polygalae radix and its processed products in combating brain aging.
  • Utilized UPLC-Q-TOF-MS for component identification
  • Applied network pharmacology and molecular docking to explore interactions
  • Conducted in vivo assays to evaluate memory and hippocampal health.
  • Thirteen brain-penetrating components were identified, contributing to anti-aging effects.
  • PT and its processed products improved memory and reduced hippocampal damage.
  • Enhanced antioxidant capacity linked to modulation of mitochondrial dynamics and BDNF.

Cite This Study

Fan et al. (2026) studied this question.

synapsesocial.com/papers/69e9bb9e85696592c86ed346https://doi.org/10.1002/bmc.70458
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Also Consider

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  1. 1Evaluation of In Situ Antiaging Activity in Saccharomyces cerevisiae BY611 Yeast Cells Treated with Polyalthia longifolia Leaf Methanolic Extract (PLME) Using Different Microscopic Approaches: A Morphology-Based Evaluation2022 · 6 citations
  2. 2Comprehensive evaluation of chemical constituents and antioxidant activity between crude and processed Polygalae radix based on UPLC-Q-TOF-MS/MS combined with multivariate statistical analysis2024 · 7 citations
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  4. 4Neuroprotective Effects and Mechanisms of Senegenin, an Effective Compound Originated From the Roots of Polygala Tenuifolia2022 · 34 citations