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December 8, 2025Natural Product Research

Phytochemical profiling and cognitive enhancement effects of Astragalus peregrinus extract and its nanostructured lipid carrier in a D-galactose-induced aging rat model

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Authors

HAHanan F. Aly

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Overview

Phytochemical profiling improves cognitive performance in a D-galactose aging model, indicating potential for therapeutic intervention.

Key Points

  • This research aims to explore the effects of Astragalus peregrinus extract on cognitive impairment due to brain ageing.
  • Developed a nanoformulation of Astragalus peregrinus for enhanced drug delivery.
  • Evaluated DPPH radical scavenging and AChE inhibitory properties of the extract and its nanoformulation.
  • Used UPLC-QTOF-HRMS/MS to analyze the metabolic profile of the extract.
  • Compared the effects of the extract and nanoformulation against Donepezil in a rat model.
  • Astragalus peregrinus extract showed high antioxidant activity and effective cognitive enhancement.
  • Both the extract and its nanostructured lipid carrier alleviated D-galactose-induced brain ageing.
  • Administration led to improved brain function and cognitive performance in the rat model.
  • Histopathological recovery was significantly prompted by the treatment.

Cite This Study

Hanan F. Aly (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d832https://doi.org/10.1080/14786419.2025.2596877
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