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September 10, 2025Tropical Journal of Natural Product ResearchOpen Access

PEG-400 Nanoencapsulated Gotu Kola Leaf Extracts as an Alternative Treatment for Cognitive System Impairment: In-Vitro and In-Vivo Assays

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Authors

BLBrian LimantoroDSDidier SamuelANAqillah N Naufaldy

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Overview

In vivo analysis improves cognitive performance in mice, suggesting PEG-400 enhances bioavailability and blood-brain barrier penetration.

Key Points

  • The PEG-400 nanoencapsulated formulation reduced maze completion time by 1.44 seconds and TNF-α levels by 19.9%.
  • Nanoparticle characterization showed 5-7 nm spherical particles with excellent blood-brain barrier penetration potential.
  • Ellman’s assay confirmed 100% acetylcholinesterase inhibition for key formulations, highlighting neuroprotective effects.
  • Findings support the potential of Gotu Kola extracts in treating cognitive decline with implications for elderly care.

Cite This Study

Limantoro et al. (2025) studied this question.

synapsesocial.com/papers/68c1a41654b1d3bfb60defdbhttps://doi.org/10.26538/tjnpr/v9i7.22
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