Key result
Ross procedure linked to ~13% greater 10-year event-free survival vs mechanical AVR in children.
Why the study?
Several options exist for aortic valve replacement, but comparative reports are scarce and the optimal choice for each age group is unclear.
Does the Ross procedure improve event-free survival compared to mechanical or bioprosthetic AVR in children and young adults?
Cohort (n=1,501)
Yes
Does the Ross procedure improve event-free survival compared to mechanical or bioprosthetic AVR in children and young adults?
Effect estimate: 12.7% higher
p-value: p=0.05
The Ross procedure offers superior event-free survival and overall survival approaching the general population compared to mechanical or bioprosthetic AVR in children and young adults, though pulmonary homograft reintervention remains a long-term consideration.
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Supports Ross over mechanical AVR in children but should not yet change practice; leaves open randomized confirmation.
Sharabiani et al. (2016) conducted a cohort in Aortic valve disease requiring replacement (n=1,501). Ross procedure vs. Mechanical, bioprosthesis, and homograft aortic valve replacement was evaluated on Event-free probability (death or any reintervention) at 10 years in children (12.7% higher, p=0.05). The Ross procedure demonstrated a 12.7% higher event-free probability at 10 years compared to mechanical aortic valve replacement in children (p=0.05).
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