This review highlights phytochemicals' therapeutic potential to enhance mitochondrial quality control in Alzheimer’s disease, suggesting promising neuroprotective strategies.
Key Points
Examine how mitochondrial quality control dysfunction contributes to Alzheimer's disease and explore phytochemicals as therapeutic agents.
Review of current evidence on mitochondrial quality control mechanisms in Alzheimer's disease.
Analysis of phytochemicals that restore mitochondrial functions including biogenesis and mitophagy.
Identification of challenges in translating phytochemical strategies to clinical use.
Phytochemicals enhance mitochondrial biogenesis and mitophagy, improving mitochondrial function in models of Alzheimer's disease.
They alleviate oxidative stress and prevent mitochondria-dependent apoptosis in neurons.
Challenges include poor bioavailability and the need for clinical validation of phytochemical therapies.