A CatBoost machine learning model utilizing plasma proteomic profiles identified 36 proteins significantly associated with hypertension and achieved an AUROC of 0.7985 for classifying stage 1 hypertension.
Observational (n=778)
Explainable machine learning identified a distinct 36-protein signature, driven by Renin, TFPI, sRAGE, and QORL1, that accurately classifies stage 1 hypertension.
Effect estimate: AUROC 0.7985
Abstract Hypertension is a major global health burden and a leading driver of cardiovascular disease, yet reliable blood-based biomarkers for early disease are still limited. We combined plasma proteomics with explainable machine learning to identify circulating proteins associated with stage 1 hypertension in the Qatar Biobank. Proteomic profiles from 778 participants (554 controls and 224 stage 1 hypertension cases) were analyzed; 1305 proteins were tested for differential expression with adjustment for age and sex, and top features were prioritized before training predictive models. Among the evaluated classifiers, CatBoost performed best (AUROC = 0.7985), and SHapley Additive exPlanations were used to interpret the model. We identified 36 proteins significantly associated with hypertension and observed a characteristic pattern featuring lower Renin, sRAGE, ghrelin, and IL-1RAcP, and higher TFPI, QORL1, HSP70, and C5a in hypertensive individuals. Pathway and network analyses implicated processes related to oxidative stress and vascular function. Together, these results demonstrate Renin, TFPI, sRAGE, QORL1, ghrelin, HSP70, IL-1RAcP, and C5a as candidate circulating biomarkers for hypertension and illustrate the value of explainable AI for translating proteomic signals into potentially clinically interpretable candidates, pending validation in independent and diverse cohorts.
Sekaran et al. (Wed,) conducted a observational in Stage 1 hypertension (n=778). Plasma proteomics and machine learning (CatBoost) vs. Healthy controls was evaluated on Model performance (AUROC) for classifying stage 1 hypertension (AUROC 0.7985). A CatBoost machine learning model utilizing plasma proteomic profiles identified 36 proteins significantly associated with hypertension and achieved an AUROC of 0.7985 for classifying stage 1 hypertension.