Premenopausal and postmenopausal obesity and endometrial cancer risk: circulating biomarkers of inflammation, insulin resistance, and sex hormones as mediators

Sabrina E. Wang; Vivian Viallon; Carine Biessy; Tracy O'Mara; Maria Kyrgiou; Laura Burney Ellis; Emma J Crosbie; Holly Baker‐Rand; James Yarmolinsky; Pekka Keski‐Rahkonen; Mattias Johansson; A. Fournier; Marianne Canonico; Sabine Naudin; Renée T. Fortner; Charlotte Le Cornet; Matthias Schulze; Marta Crous‐Bou; Maria-Jose Sánchez; Amaia Aizpurua; Natalia Cabrera Castro; Marcela Guevara; Giovanna Masala; ­Rosario ­Tumino; Marı́a Teresa Giraudo; Camilla Panico; Ruth C. Travis; Marc J Gunter; Sabina Rinaldi; S Ghazaleh Dashti; Laure Dossus

doi:10.1093/jnci/djag119

Key Points

This research aims to explore how biomarkers related to inflammation, insulin resistance, and sex hormones mediate the link between obesity and endometrial cancer risk in premenopausal and postmenopausal women.
Analyzed circulating biomarkers in different menopausal groups
Examined the relationship between obesity, cancer risk, and mediators
Compared the effects of inflammation and sex hormones on cancer risk
Sex hormones are significant mediators of the obesity-endometrial cancer link in postmenopausal women.
Inflammation-related biomarkers may primarily mediate this relationship in premenopausal women.
There are notable overlaps in the mediating pathways between obesity and endometrial cancer across menopause groups.

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Implication

Investigates obesity's impact on endometrial cancer risk in different menopausal groups, suggesting key mediators like hormones and inflammation.

Abstract

Circulating biomarkers for inflammation, insulin resistance, and sex hormones may mediate the effect of obesity on endometrial cancer risk, with some overlaps in mediating pathways. Sex hormones were the most prominent mediators in postmenopausal obesity, whereas biomarkers for inflammation may play an important role in premenopausal obesity.

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69eb08ef553a5433e34b3a96 https://doi.org/10.1093/jnci/djag119

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Premenopausal and postmenopausal obesity and endometrial cancer risk: circulating biomarkers of inflammation, insulin resistance, and sex hormones as mediators

Key Points

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Implication

Abstract

Discussion

Cite This Study

Premenopausal and postmenopausal obesity and endometrial cancer risk: circulating biomarkers of inflammation, insulin resistance, and sex hormones as mediators

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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