Premenopausal and postmenopausal obesity and endometrial cancer risk: circulating biomarkers of inflammation, insulin resistance, and sex hormones as mediators

Key Points

• This research aims to explore how biomarkers related to inflammation, insulin resistance, and sex hormones mediate the link between obesity and endometrial cancer risk in premenopausal and postmenopausal women.
• Analyzed circulating biomarkers in different menopausal groups
• Examined the relationship between obesity, cancer risk, and mediators
• Compared the effects of inflammation and sex hormones on cancer risk
• Sex hormones are significant mediators of the obesity-endometrial cancer link in postmenopausal women.
• Inflammation-related biomarkers may primarily mediate this relationship in premenopausal women.
• There are notable overlaps in the mediating pathways between obesity and endometrial cancer across menopause groups.