Metabolic syndrome, plasma lipid, lipoprotein and glucose levels, and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
Key result
The presence of metabolic syndrome was associated with a significantly increased risk of endometrial cancer (RR 2.12), which increased with the number of metabolic syndrome factors.
Why the study?
Do prediagnostic metabolic syndrome, plasma lipids, lipoproteins, and glucose levels increase the risk of endometrial cancer in women?
Population
830 pre- and postmenopausal women from the European Prospective Investigation into Cancer and Nutrition…
Comparison
High levels of plasma lipids, lipoproteins… vs Low levels of plasma lipids, lipoproteins…
Design
Case-control
Authors
Discussion
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Implication
Metabolic syndrome may elevate endometrial cancer risk; hypothesis-generating for prevention trials but should not yet change practice.
Study Design
Type
Case-Control (n=830)
Multicenter
Yes
Structured PICO
Do prediagnostic metabolic syndrome, plasma lipids, lipoproteins, and glucose levels increase the risk of endometrial cancer in women?
P
Population
830 pre- and postmenopausal women (284 incident endometrial cancer cases and 546 matched controls) from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
I
Intervention
High levels of plasma lipids, lipoproteins, glucose, and presence of metabolic syndrome (MetS)
C
Comparator
Low levels of plasma lipids, lipoproteins, glucose, and absence of metabolic syndrome
O
Outcome
Endometrial cancer riskhard clinical
Main Result
Effect estimate: RR 2.12 (95% CI 1.51-2.97)
Metabolic abnormalities and obesity may act synergistically to increase the risk of endometrial cancer in women.
Limitations
- Mixture of fasting and non-fasting blood samples
- Use of a single measurement from one baseline blood sample that does not fully reflect long-term circulating levels
- Lack of data on pharmacologic treatments for hypertension, hypertriglyceridemia, or low HDL-C
Cite This Study
Cust et al. (2007) conducted a case-control in Endometrial cancer (n=830). Metabolic syndrome (NCEP definition) vs. Absence of metabolic syndrome was evaluated on Incident endometrial cancer (RR 2.12, 95% CI 1.51-2.97). The presence of metabolic syndrome was associated with a significantly increased risk of endometrial cancer (RR 2.12), which increased with the number of metabolic syndrome factors.